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Invitrogen
ORM2 Polyclonal Antibody
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FIGURE: 1 / 4
ORM2 Antibody (PA5-37124) in IHC (P)
Immunohistochemistry analysis of ORM2 in paraffin-embedded human tonsil carcinoma tissue (cytoplasmic and nucleus staining) and negative control (right, with PBS only). Samples were incubated with ORM2 polyclonal antibody (Product # PA5-37124) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-37124
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human AGP-2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 24 and 45 kDa.
Purity is >95% by SDS-PAGE.
Target Information
AGP (a 1-acid Glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/mL, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3 and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AGP 2; alpha-1-acid glycoprotein 1; Alpha-1-acid glycoprotein 2; alpha-1-acid glycoprotein, type 2; bM340H1.5 (orosomucoid 2); OMD 2; OMD2; ORM2; Orosomucoid-2; Orosomucoid2; unnamed protein product
Gene Aliases: Agp-2; AGP-B; AGP-B'; Agp1; AGP2; Orm-2; ORM2
UniProt ID: (Human) P19652, (Mouse) P07361
Entrez Gene ID: (Human) 5005, (Mouse) 18406
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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