Immunogen sequence: NKKKLFMIYG KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA QETVQVIPGS KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT DCRLRPDIRG MENGNMDLAS QEKERLEEKQ REARRERAKE EAEWQTRWFY PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY; Positive Samples: U-251MG, A549, HepG2, HeLa
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
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Protein Aliases: ORP-2; OSBP-related protein 2; oxysterol binding protein-like 2; oxysterol-binding protein-like 2; Oxysterol-binding protein-related protein 2
Gene Aliases: C130070J12Rik; DFNA67; DNFA67; KIAA0772; mKIAA0772; ORP-2; ORP2; OSBPL2