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Positive test controls include: 293T, HeLa, BT-474, NIH/3T3, Mouse brain, Mouse kidney, Mouse liver, Rat brain. The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, cytosol, perinuclear region.^M
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Immunogen sequence: LEENGYRSLC EQVSHHPPAA AHHAESKNGW TLRQEIKITS KFRGKYLSIM PLGTIHCIFH ATGHHYTWKK VTTTVHNIIV GKLWIDQSGE IDIVNHKTGD KCNLKFVPYS YFSRDVARKV TGEVTDPSGK VHFALLGTWD EKMECFKVQP VIGENGGDAR QRGHEAEESR VMLWKRNPLP KNAENMYYFS ELALTLNAWE SGTAPTDSRL RPDQRLMENG RWDEANAEKQ RLEEKQRLSR KKREAEAMKA TEDGTPYDPY KALWFERKKD PVTKELTHIY RGEYWECKEK QDWSSCPDIF
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase.
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Protein Aliases: HGNC:8503; Oxysterol-binding protein 1
Gene Aliases: 1110018F06Rik; AW559088; Kiaa4220; mKIAA4220; OSBP; OSBP1
UniProt ID: (Human) P22059, (Mouse) Q3B7Z2
Entrez Gene ID: (Human) 5007, (Mouse) 76303, (Rat) 365410
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