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Bioss
OTUB Polyclonal Antibody
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FIGURE: 1 / 1
OTUB Antibody (BS-6236R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with OTUB Polyclonal Antibody, Unconjugated (bs-6236R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-6236R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human OTUB.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme OTUB1; deubiquitinating enzyme OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; Deubiquitinating enzyme OTUB2; hOTU1; OTU domain, ubiquitin aldehyde binding 1; OTU domain, ubiquitin aldehyde binding 2; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250|UniProtKB:Q7TQI3}; OTU domain-containing ubiquitin aldehyde-binding protein 2; OTU-domain Ubal-binding 1; otub1 {ECO:0000312|EMBL:AAI66771.1}; otubain 1; Otubain-1; otubain-1 {ECO:0000250|UniProtKB:Q7TQI3}; Otubain-2; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; Ubiquitin thioesterase OTUB2; ubiquitin-specific protease otubain 1; ubiquitin-specific protease otubain 2; Ubiquitin-specific-processing protease OTUB1; ubiquitin-specific-processing protease OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; Ubiquitin-specific-processing protease OTUB2
Gene Aliases: 2010015L18Rik; 4930586I02Rik; AI413508; AI850305; AW557219; C14orf137; HSPC263; OTB1; OTB2; OTU1; OTU2; OTUB1; OTUB2
UniProt ID: (Human) Q96FW1, (Human) Q96DC9, (Mouse) Q7TQI3, (Rat) B2RYG6, (Mouse) Q9CQX0
Entrez Gene ID: (Human) 55611, (Human) 78990, (Mouse) 107260, (Rat) 293705, (Mouse) 68149, (Rat) 314405
adaptive immune response
DNA repair
cellular response to DNA damage stimulus
protein K48-linked deubiquitination
cellular response to interleukin-1
negative regulation of histone H2A K63-linked ubiquitination
negative regulation of double-strand break repair
protein deubiquitination
protein K11-linked deubiquitination
protein K63-linked deubiquitination
immune system process
proteolysis
cellular amino acid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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