Invitrogen

OX40L Polyclonal Antibody

View all (19) OX40L (CD252) antibodies

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OX40L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of OX40L in human hepatoma with OX40L Polyclonal Antibody (Product # PA5-81277, 1:1,000, formalin-fixed paraffin embedded sections).

OX40L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of OX40L in human rectum with OX40L Polyclonal Antibody (Product # PA5-81277, 1:1,000, formalin-fixed paraffin embedded sections).

OX40L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of OX40L in mouse liver with OX40L Polyclonal Antibody (Product # PA5-81277, 1:1,000, formalin-fixed paraffin embedded sections).

OX40L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of OX40L in mouse colon with OX40L Polyclonal Antibody (Product # PA5-81277, 1:1,000, formalin-fixed paraffin embedded sections).

Product Details

PA5-81277

Applications	Tested Dilution	Publications
Immunohistochemistry (Paraffin) (IHC (P))	1:500-1:2,000	-

Product Specifications
Species Reactivity	Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthetic peptide corresponding to the N-terminus of the Mouse OX-40L/TNFSF4/CD252 View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A, Antigen affinity chromatography
Storage buffer	PBS
Contains	no preservative
Storage conditions	Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
RRID	AB_2788498

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Mouse OX40L.

Target Information

The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: atherosclerosis 1; CD252; OX40 ligand; OX40L; tax-transcriptionally activated glycoprotein 1 ligand; Tumor necrosis factor ligand superfamily member 4

Gene Aliases: Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l; Tnfsf4; TXGP1; Txgp1l

UniProt ID: (Mouse) P43488

Entrez Gene ID: (Mouse) 22164

blood vessel development cytokine production defense response to nematode acute inflammatory response positive regulation of immune effector process positive regulation of T cell cytokine production regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of immunoglobulin mediated immune response inflammatory response immune response cholesterol metabolic process response to virus negative regulation of interferon-gamma production negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production memory T cell activation T-helper 2 cell activation response to nitrogen dioxide cellular response to nitrogen dioxide CD4-positive, alpha-beta T cell costimulation T cell proliferation positive regulation of activated T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of memory T cell differentiation negative regulation of sequence-specific DNA binding transcription factor activity innate immune response negative regulation of regulatory T cell differentiation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated positive regulation of alpha-beta T cell proliferation negative regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response positive regulation of B cell activation positive regulation of immunoglobulin secretion negative regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus chemokine (C-C motif) ligand 11 production positive regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of T cell migration positive regulation of T cell costimulation positive regulation of memory T cell activation positive regulation of T-helper 2 cell activation positive regulation of interleukin-4-dependent isotype switching to IgE isotypes negative regulation of extrinsic apoptotic signaling pathway

Process(es)

cytokine activity tumor necrosis factor receptor binding tumor necrosis factor receptor superfamily binding