Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%).
TG1019 is a G protein-coupled receptor that functions as a chemoattractant for eosinophils and neutrophils. TG1019 is expressed in various tissues except the brain, with the highest expression in liver, kidney, peripheral leukocyte, lung and spleen. TG1019 interacts with the protein OXE to form TG1019/OXE, a Galpha i/o protein-coupled receptor. Signals from TG1019 are transduced via a Galpha i/o protein to PLC/calcium, MEK/ERK and PI3K/Akt pathways. Signal transduction from TG1019 following stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE) induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt pathways. TG1019 also may play a role in downregulating cAMP production.
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Protein Aliases: 5-oxo-ETE acid G-protein-coupled receptor 1; 5-oxo-ETE G-protein coupled receptor; G-protein coupled receptor 170; G-protein coupled receptor R527; G-protein coupled receptor TG1019; GPR170; HEOAD54; OXE receptor; OXER1; Oxoeicosanoid (OXE) receptor 1; Oxoeicosanoid receptor 1; TG1019
Gene Aliases: GPCR; GPR170; OXER1; TG1019
UniProt ID: (Human) Q8TDS5
Entrez Gene ID: (Human) 165140