Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MSFQKPKGT IEYTVESRDS LNSIALKFDT TPNELVQLNK LFSRAVVTGQ VLYVPDPEYV SSVESSPSLS PVSPLSPTSS EAEFDKTTNP DVHPTEATPS STFTGIRPAR VVSSTSEEEE AFTEKFLKIN CKYITSGKGT VSGVLLVTPN NIMFDPHKND PLVQENGCEE YGIMCPMEEV MSAAMYKEIL DSKIKESLPI DIDQLSGRDF CHSKKMTGSN TEEIDSRIRD AGNDSASTAP RSTEESLSED VFTESELSPI REELVSSDEL RQDKSSGASS ESVQTVNQAE VESLTVKSES TGTPGHLRSD TEHSTNEVGT LCHKTDLNNL EMAIKEDQIA DNFQGISGPK ED (1-351 aa encoded by BC032710)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
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Protein Aliases: nucleolar protein C7; Oxidation resistance protein 1; Protein C7; putative protein product of Nbla00307; TBC/LysM-associated domain containing 3
Gene Aliases: 2210416C20Rik; C7; C7B; Gm1238; Nbla00307; OXR1; TLDC3
UniProt ID: (Human) Q8N573, (Mouse) Q4KMM3
Entrez Gene ID: (Human) 55074, (Mouse) 170719
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