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Invitrogen
Opsin 3 Polyclonal Antibody
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FIGURE: 1 / 6
Opsin 3 Antibody (PA5-106831) in IHC (P)
Immunohistochemistry analysis of Opsin 3 in mouse colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Opsin 3 polyclonal antibody (Product # PA5-106831) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106831
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human OPN3(Accession Q9H1Y3), corresponding to amino acid residues A169-A219.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total OPN3.
Target Information
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. May play a role in encephalic photoreception. Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Encephalopsin; extraretinal opsin; multiple tissue opsin; NMO-1; opsin (encephalopsin); opsin 3 (encephalopsin, panopsin); Opsin-3; Panopsin; protein phosphatase 1, regulatory subunit 116
Gene Aliases: ECPN; ERO; OPN3; PPP1R116
UniProt ID: (Human) Q9H1Y3, (Mouse) Q9WUK7
Entrez Gene ID: (Human) 23596, (Rat) 498289, (Mouse) 13603
signal transduction
G-protein coupled receptor signaling pathway
phototransduction
detection of light stimulus
detection of visible light
response to blue light
positive regulation of metabolic process
keratinocyte differentiation
regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of glucose import
negative regulation of melanin biosynthetic process
positive regulation of melanin biosynthetic process
cellular response to light stimulus
cellular response to UV-A
positive regulation of cellular respiration
protein-chromophore linkage
response to stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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