This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
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Protein Aliases: Hcrt; Hcrt1; Hcrt2; Hypocretin; Hypocretin (orexin) neuropeptide; Hypocretin-1; Hypocretin-2; Orexin; orexin A; orexin B; Orexin-A; Orexin-B; prepro-orexin
Gene Aliases: Hcrt; orexin-A; Ox; PPOX