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Proteintech
Oxytocin Receptor Polyclonal Antibody
Product Details
23045-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Flow Cytometry (Flow) |
0.2 µg/1x10^6 cells | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Oxytocin Receptor Fusion Protein Ag19074 (326-389 aa encoded by BC137443) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.39 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
This antibody is raised against the C-terminal region of human OXTR.
Immunogen sequence: PWIYMLFTG HLFHELVQRF LCCSASYLKG RRLGETSASK KSNSSSFVLS HRSSSQRSCS QPSTA (326-389 aa encoded by BC137443)
Target Information
The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: OT-R; Oxt-r; Oxytocin receptor
Gene Aliases: OT-R; OXTR
UniProt ID: (Human) P30559
Entrez Gene ID: (Human) 5021
Molecular Function:
G-protein coupled receptor
suckling behavior
response to amphetamine
regulation of systemic arterial blood pressure by vasopressin
muscle contraction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
heart development
female pregnancy
lactation
memory
positive regulation of norepinephrine secretion
telencephalon development
sleep
positive regulation of synaptic transmission, GABAergic
response to estradiol
response to progesterone
cellular response to hormone stimulus
response to anoxia
response to cytokine
social behavior
response to cocaine
response to drug
maternal behavior
sperm ejaculation
eating behavior
response to peptide hormone
estrous cycle
positive regulation of blood pressure
positive regulation of vasoconstriction
digestive tract development
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
maternal process involved in parturition
positive regulation of penile erection
negative regulation of gastric acid secretion
ERK1 and ERK2 cascade
positive regulation of uterine smooth muscle contraction
response to peptide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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