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Proteintech
Oxytocin Receptor Polyclonal Antibody
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Product Details
23045-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Oxytocin Receptor Fusion Protein Ag19074 (326-389 aa encoded by BC137443)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is raised against the C-terminal region of human OXTR.
Immunogen sequence: PWIYMLFTG HLFHELVQRF LCCSASYLKG RRLGETSASK KSNSSSFVLS HRSSSQRSCS QPSTA (326-389 aa encoded by BC137443)
Target Information
The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G-protein coupled receptor; OT-R; Oxt-r; Oxytocin receptor; unnamed protein product
Gene Aliases: OT-R; OTR; OXTR
UniProt ID: (Human) P30559
Entrez Gene ID: (Human) 5021
regulation of systemic arterial blood pressure by vasopressin
system process
muscle contraction
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
female pregnancy
lactation
cellular response to hormone stimulus
positive regulation of blood pressure
positive regulation of vasoconstriction
maternal process involved in parturition
regulation of biological quality
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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