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Alomone Labs, LTD
Oxytocin Receptor Polyclonal Antibody
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FIGURE: 1 / 2
Oxytocin Receptor Antibody (AVR-013-200UL) in IHC (F)
Expression ofOxytocynReceptor in rat midbrain. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Oxytocin Receptor Antibody (#AVR-013), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. Oxytocyn Receptor immunoreactivity (green) appears in neuronal profiles (arrows) in the substantia nigra pars compacta (SNC). B. Pre-incubation of the Antibody with Oxytocin Receptor ... View More
Product Details
AVR-013-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CSARYLKGSRPGE, corresponding to amino acid residues 346-358 of rat Oxtr, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Amount
170 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OT-R; oxcytocin receptor; Oxt-r; Oxytocin receptor
Gene Aliases: OTR; OTR1; Oxtr
UniProt ID: (Mouse) P97926, (Rat) P70536
Entrez Gene ID: (Mouse) 18430, (Rat) 25342
suckling behavior
response to amphetamine
regulation of systemic arterial blood pressure by vasopressin
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
female pregnancy
lactation
memory
positive regulation of norepinephrine secretion
sleep
positive regulation of synaptic transmission, GABAergic
cellular response to hormone stimulus
response to anoxia
social behavior
maternal behavior
sperm ejaculation
eating behavior
regulation of digestive system process
positive regulation of blood pressure
positive regulation of vasoconstriction
response to steroid hormone
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
positive regulation of penile erection
negative regulation of gastric acid secretion
ERK1 and ERK2 cascade
positive regulation of uterine smooth muscle contraction
response to peptide
heart development
response to organic cyclic compound
telencephalon development
response to estradiol
response to progesterone
response to cytokine
response to cocaine
response to drug
response to peptide hormone
estrous cycle
digestive tract development
maternal process involved in parturition
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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