Search
Invitrogen
P-Glycoprotein Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
P-Glycoprotein Antibody (PA5-120134) in WB
Western blot analysis of P-Glycoprotein in extracts of various cell lines. Samples were incubated with P-Glycoprotein Polyclonal antibody (Product # PA5-120134) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-120134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 603-692 of human P Glycoprotein (NP_000918.2).
Conjugate
Form
Liquid
Concentration
1.19 mg/mL
Amount
119 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Mouse liver, Mouse brain. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Immunogen sequence: DGVIVEKGNH DELMKEKGIY FKLVTMQTAG NEVELENAAD ESKSEIDALE MSSNDSRSSL IRKRSTRRSV RGSQAQDRKL STKEALDESI
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B, member 1A; ATP-dependent translocase ABCB1; CD243; ecotropic viral integration site 32; MDR1A; multi-drug resistance 3; multidrug resistance protein 1; Multidrug resistance protein 1A; Multidrug resistance protein 1B; Multidrug resistance protein 3; multiple drug resistant 1a; P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; Phospholipid transporter ABCB1
Gene Aliases: Abcb1; Abcb1a; Abcb1b; Abcb4; Evi32; mdr; mdr-3; Mdr1; Mdr1a; Mdr1b; Mdr3; P-gp; Pgp; Pgy-1; Pgy-3; Pgy1; Pgy1-1; Pgy3
UniProt ID: (Mouse) P21447, (Mouse) P06795
Entrez Gene ID: (Mouse) 18671, (Mouse) 18669
G2/M transition of mitotic cell cycle
transport
drug transmembrane transport
hormone transport
drug transport
xenobiotic transport
daunorubicin transport
drug export
transmembrane transport
negative regulation of cell death
establishment of blood-brain barrier
stem cell proliferation
positive regulation of response to drug
establishment of endothelial blood-brain barrier
response to drug
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support