This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
Recommended positive controls: HepG2, HepG2 membrane fraction extract, unboild HepG2, unboiled HepG2 membrane fraction extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1
Gene Aliases: ABC20; ABCB1; CD243; CLCS; GP170; MDR1; P-GP; PGY1
UniProt ID: (Human) P08183
Entrez Gene ID: (Human) 5243
Molecular Function: ATP-binding cassette (ABC) transporter