Product References
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
OncoTargets and therapy
Ling Z,Guan H,You Z,Wang C,Hu L,Zhang L,Wang Y,Chen S,Xu B,Chen M
Sun Apr 10 00:00:00 EDT 2022
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
OncoTargets and therapy
Liu X,Zhao Y,Zhang W,Gao Y,Huo M,Liu M,Xiao Z,Liang S,Xu N,Zhu H
Thu Mar 17 00:00:00 EDT 2022
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
OncoTargets and therapy
Liu X,Zhao Y,Zhang W,Gao Y,Huo M,Liu M,Xiao Z,Liang S,Xu N,Zhu H
Thu Mar 17 00:00:00 EDT 2022
Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Cell & bioscience
Sun W,Yang J,Zhang Y,Xi Y,Wen X,Yuan D,Wang Y,Wei C,Wang R,Wu L,Li H,Xu C
Fri Mar 11 00:00:00 EST 2022
Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells.
American journal of translational research
Chen ZH,Hu HK,Zhang CR,Lu CY,Bao Y,Cai Z,Zou YX,Hu GH,Jiang L
Wed Jan 12 00:00:00 EST 2022
Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21, P27 and p38MAPK/MMP-9.
International journal of ophthalmology
Hao XN,Wang WJ,Chen J,Zhou Q,Qu YX,Liu XY,Xu W
Thu Oct 01 00:00:00 EDT 2020
Histone deacetylase inhibitor NaBut suppresses cell proliferation and induces apoptosis by targeting p21 in multiple myeloma.
American journal of translational research
Yao R,Han D,Sun X,Fu C,Wu Q,Yao Y,Li H,Li Z,Xu K
Thu Oct 01 00:00:00 EDT 2020
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Frontiers in cellular neuroscience
Deng X,Song L,Zhao W,Wei Y,Guo XB
Wed Sep 30 00:00:00 EDT 2020
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
Frontiers in cellular and infection microbiology
Wang Z,Wang Y,Wang S,Meng X,Song F,Huo W,Zhang S,Chang J,Li J,Zheng B,Liu Y,Zhang Y,Zhang W,Yu J
Fri Aug 16 00:00:00 EDT 2019
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Journal of cellular physiology
Pan JH,Zhou H,Zhu SB,Huang JL,Zhao XX,Ding H,Qin L,Pan YL
Mon Apr 01 00:00:00 EDT 2019
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liang X,Ding Y,Lin F,Zhang Y,Zhou X,Meng Q,Lu X,Jiang G,Zhu H,Chen Y,Lian Q,Fan H,Liu Z
Fri Mar 01 00:00:00 EST 2019
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Experimental eye research
Wei X,Luo D,Yan Y,Yu H,Sun L,Wang C,Song F,Ge H,Qian H,Li X,Tang X,Liu P
Fri Mar 01 00:00:00 EST 2019
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Experimental eye research
Wei X,Luo D,Yan Y,Yu H,Sun L,Wang C,Song F,Ge H,Qian H,Li X,Tang X,Liu P
Fri Mar 01 00:00:00 EST 2019
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Cancers
Chen YA,Tzeng DTW,Huang YP,Lin CJ,Lo UG,Wu CL,Lin H,Hsieh JT,Tang CH,Lai CH
Mon Dec 31 00:00:00 EST 2018
Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.
Biochemical and biophysical research communications
Chen M,Zhang H,Zhang G,Zhong A,Ma Q,Kai J,Tong Y,Xie S,Wang Y,Zheng H,Guo L,Lu R
Sun Dec 09 00:00:00 EST 2018
Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.
Biochemical and biophysical research communications
Chen M,Zhang H,Zhang G,Zhong A,Ma Q,Kai J,Tong Y,Xie S,Wang Y,Zheng H,Guo L,Lu R
Sun Dec 09 00:00:00 EST 2018
A pH probe inhibits senescence in mesenchymal stem cells.
Stem cell research & therapy
Wang L,Han X,Qu G,Su L,Zhao B,Miao J
Fri Dec 07 00:00:00 EST 2018
S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells.
Molecules (Basel, Switzerland)
Fan Y,Mao Y,Cao S,Xia G,Zhang Q,Zhang H,Qiu F,Kang N
Sat Dec 01 00:00:00 EST 2018
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Cancer science
Liu L,Sun Y,Zhao Y,Wang Q,Guo H,Guo R,Liu Y,Fu S,Zhang L,Li Y,Meng Y
Sat Dec 01 00:00:00 EST 2018
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
Acta pharmacologica Sinica
Yang HW,Hong HL,Luo WW,Dai CM,Chen XY,Wang LP,Li Q,Li ZQ,Liu PQ,Li ZM
Sat Dec 01 00:00:00 EST 2018
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Molecular pharmaceutics
Chen X,Liu C,Zhao R,Zhao P,Wu J,Zhou N,Ying M
Mon Nov 05 00:00:00 EST 2018
The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo.
FEBS letters
Yu M,Wang H,Liu J,Qin H,Liu S,Yan Q
Thu Nov 01 00:00:00 EDT 2018
Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy.
Archives of biochemistry and biophysics
Wen W,Chen J,Ding L,Luo X,Zheng X,Dai Q,Gu Q,Liu C,Liang M,Guo X,Liu P,Li M
Thu Nov 01 00:00:00 EDT 2018
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
Molecular cancer
Xie F,Li Y,Wang M,Huang C,Tao D,Zheng F,Zhang H,Zeng F,Xiao X,Jiang G
Wed Oct 03 00:00:00 EDT 2018
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Mechanisms of ageing and development
Xing SS,Li J,Chen L,Yang YF,He PL,Li J,Yang J
Mon Oct 01 00:00:00 EDT 2018
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Mechanisms of ageing and development
Xing SS,Li J,Chen L,Yang YF,He PL,Li J,Yang J
Mon Oct 01 00:00:00 EDT 2018
SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Li Z,Qiu R,Qiu X,Tian T
Tue Sep 18 00:00:00 EDT 2018
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
Arteriosclerosis, thrombosis, and vascular biology
Badi I,Mancinelli L,Polizzotto A,Ferri D,Zeni F,Burba I,Milano G,Brambilla F,Saccu C,Bianchi ME,Pompilio G,Capogrossi MC,Raucci A
Sat Sep 01 00:00:00 EDT 2018
Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Bao Y,Zhang S,Guo Y,Wei X,Zhang Y,Yang Y,Zhang H,Ma M,Yang W
Sat Sep 01 00:00:00 EDT 2018
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Bioscience reports
Liu L,Sun X,Xie Y,Zhuang Y,Yao R,Xu K
Fri Aug 31 00:00:00 EDT 2018
Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A.
Biochemical and biophysical research communications
Xue X,Wang X,Zhao Y,Hu R,Qin L
Sat Aug 25 00:00:00 EDT 2018
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Cell and tissue research
Zhang T,Wang P,Liu Y,Zhou J,Shi Z,Cheng K,Huang T,Wang X,Yang GL,Yang B,Ma S,Guan F
Wed Aug 01 00:00:00 EDT 2018
Suppressed epithelial-mesenchymal transition and cancer stem cell properties mediate the anti-cancer effects of ethyl pyruvate via regulation of the AKT/nuclear factor-κB pathway in prostate cancer cells.
Oncology letters
Huang B,Lv DJ,Wang C,Shu FP,Gong ZC,Xie T,Yu YZ,Song XL,Xie JJ,Li S,Liu YM,Qi H,Zhao SC
Wed Aug 01 00:00:00 EDT 2018
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Wu F,Li S,Zhang N,Huang W,Li X,Wang M,Bai D,Han B
Wed Aug 01 00:00:00 EDT 2018
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Wu F,Li S,Zhang N,Huang W,Li X,Wang M,Bai D,Han B
Wed Aug 01 00:00:00 EDT 2018
Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.
Cancer medicine
Chen SM,Lin TK,Tseng YY,Tu CH,Lui TN,Huang SF,Hsieh LL,Li YY
Wed Aug 01 00:00:00 EDT 2018
Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.
Scientific reports
Napoli E,Song G,Panoutsopoulos A,Riyadh MA,Kaushik G,Halmai J,Levenson R,Zarbalis KS,Giulivi C
Fri Jul 27 00:00:00 EDT 2018
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Aging
Luo W,Wang Y,Yang H,Dai C,Hong H,Li J,Liu Z,Guo Z,Chen X,He P,Li Z,Li F,Jiang J,Liu P,Li Z
Tue Jul 24 00:00:00 EDT 2018
Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention.
Toxicology letters
Wang J,Chen J,Jiang Y,Shi Y,Zhu J,Xie C,Geng S,Wu J,Zhang Q,Wang X,Meng Y,Li Y,Chen Y,Cao W,Wang X,Zhong C,Li X
Sun Jul 01 00:00:00 EDT 2018
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Experimental gerontology
Wang W,Cai G,Chen X
Sun Jul 01 00:00:00 EDT 2018
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.
The Journal of biological chemistry
Jiang B,Zhao W,Shi M,Zhang J,Chen A,Ma H,Suleman M,Lin F,Zhou L,Wang J,Zhang Y,Liu M,Wen S,Ouyang C,Wang H,Huang X,Zhou H,Li Q
Fri Jun 22 00:00:00 EDT 2018
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
International journal of oncology
Jia W,Jiang X,Liu W,Wang L,Zhu B,Zhu H,Liu X,Zhong M,Xie D,Huang W,Jia W,Li S,Liu X,Zuo X,Cheng D,Dai J,Ren C
Fri Jun 01 00:00:00 EDT 2018
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Molecular medicine reports
Wang H,Zhong Q,Yang T,Qi Y,Fu M,Yang X,Qiao L,Ling Q,Liu S,Zhao Y
Tue May 01 00:00:00 EDT 2018
Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ye P,Ke X,Zang X,Sun H,Dong Z,Lin J,Wang L,Liu W,Miao G,Tan Y,Tong W,Xiao H,Gao L
Tue May 01 00:00:00 EDT 2018
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Antioxidants & redox signaling
Ren T,Wang J,Zhang H,Yuan P,Zhu J,Wu Y,Huang Q,Guo X,Zhang J,Ji L,Li J,Zhang H,Yang H,Xing J
Fri Apr 20 00:00:00 EDT 2018
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Journal of proteome research
Yang F,Yi M,Liu Y,Wang Q,Hu Y,Deng H
Fri Mar 02 00:00:00 EST 2018
H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing.
Oxidative medicine and cellular longevity
Wu W,Hou CL,Mu XP,Sun C,Zhu YC,Wang MJ,Lv QZ
Fri Mar 02 00:00:00 EST 2018
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Stem cells (Dayton, Ohio)
Guo XB,Deng X,Wei Y
Thu Mar 01 00:00:00 EST 2018
Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.
Journal of the Endocrine Society
Uesato T,Ogihara T,Hara A,Iida H,Miyatsuka T,Fujitani Y,Takeda S,Watada H
Thu Mar 01 00:00:00 EST 2018
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
Aging cell
Liu A,Guo E,Yang J,Yang Y,Liu S,Jiang X,Hu Q,Dirsch O,Dahmen U,Zhang C,Gewirtz DA,Fang H
Thu Feb 01 00:00:00 EST 2018
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Cell death & disease
Shen H,Zhan M,Zhang Y,Huang S,Xu S,Huang X,He M,Yao Y,Man M,Wang J
Mon Jan 22 00:00:00 EST 2018
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Journal of translational medicine
Zhang ZF,Zhang HR,Zhang QY,Lai SY,Feng YZ,Zhou Y,Zheng SR,Shi R,Zhou JY
Fri Jan 19 00:00:00 EST 2018
NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression.
Cell death & disease
Yang F,Xu Y,Liu C,Ma C,Zou S,Xu X,Jia J,Liu Z
Tue Jan 09 00:00:00 EST 2018
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Oncotarget
Zhang J,Yuan JP,Wang Q,Shao LH,Liu SP,Firestone RA,Hong YP,Li JG,Xin YC,Li Y
Fri Jan 05 00:00:00 EST 2018
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
International journal of molecular sciences
Zhang W,Yao F,Zhang H,Li N,Zou X,Sui L,Hou L
Tue Jan 02 00:00:00 EST 2018
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Oncotarget
Wang X,Li D,Fan L,Xiao Q,Zuo H,Li Z
Fri Dec 29 00:00:00 EST 2017
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Molecular medicine reports
Liu L,Zhang P,Guo H,Tang X,Liu L,Li J,Guo R,Cai Y,Liu Y,Li Y
Fri Dec 01 00:00:00 EST 2017
Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.
British journal of pharmacology
Liu T,Zhang Z,Yu C,Zeng C,Xu X,Wu G,Huang Z,Li W
Fri Dec 01 00:00:00 EST 2017
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Tang Q,Ji F,Wang J,Guo L,Li Y,Bao Y
Wed Nov 15 00:00:00 EST 2017
Inhibited effects of CAPE-pNO2 on cervical carcinoma in vivo and in vitro and its detected metabolites.
Oncotarget
Yao X,Tang H,Ren Q,Zhao X,Zuo H,Li Z
Tue Nov 07 00:00:00 EST 2017
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Oncotarget
Zhao W,Lu D,Liu L,Cai J,Zhou Y,Yang Y,Zhang Y,Zhang J
Tue Nov 07 00:00:00 EST 2017
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Scientific reports
Hu D,Cao S,Zhang G,Xiao Y,Liu S,Shang Y
Thu Oct 19 00:00:00 EDT 2017
Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest.
Journal of experimental & clinical cancer research : CR
Zhang J,Wen X,Liu N,Li YQ,Tang XR,Wang YQ,He QM,Yang XJ,Zhang PP,Ma J,Sun Y
Thu Oct 19 00:00:00 EDT 2017
A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms.
Journal of vascular surgery
Lu HY,Huang CY,Shih CM,Lin YW,Tsai CS,Lin FY,Shih CC
Sun Oct 01 00:00:00 EDT 2017
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
Oncotarget
Li X,Jiang Z,Feng J,Zhang X,Wu J,Chen W
Fri Sep 22 00:00:00 EDT 2017
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
Journal of the International AIDS Society
Bolduan S,Koppensteiner H,Businger R,Rebensburg S,Kunze C,Brack-Werner R,Draenert R,Schindler M
Tue Sep 19 00:00:00 EDT 2017
Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.
Anti-cancer drugs
Chong D,Ma L,Liu F,Zhang Z,Zhao S,Huo Q,Zhang P,Zheng H,Liu H
Fri Sep 01 00:00:00 EDT 2017
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Scientific reports
Tang H,Yao X,Yao C,Zhao X,Zuo H,Li Z
Tue Aug 08 00:00:00 EDT 2017
Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression.
Oncotarget
Cai Q,Jin L,Wang S,Zhou D,Wang J,Tang Z,Quan Z
Tue Jul 18 00:00:00 EDT 2017
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Oncotarget
Hu YH,Chen Q,Lu YX,Zhang JM,Lin C,Zhang F,Zhang WJ,Li XM,Zhang W,Li XN
Tue Jul 11 00:00:00 EDT 2017
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
Journal of hematology & oncology
Yu Z,Sun Y,She X,Wang Z,Chen S,Deng Z,Zhang Y,Liu Q,Liu Q,Zhao C,Li P,Liu C,Feng J,Fu H,Li G,Wu M
Thu Jun 08 00:00:00 EDT 2017
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
Scientific reports
Lin G,Zhu S,Wu Y,Song C,Wang W,Zhang Y,Chen YL,He Z
Wed Jun 07 00:00:00 EDT 2017
Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.
Scientific reports
Qi Y,Li X,Chang C,Xu F,He Q,Zhao Y,Wu L
Wed May 24 00:00:00 EDT 2017
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Oncotarget
Ma Y,Fu HL,Wang Z,Huang H,Ni J,Song J,Xia Y,Jin WL,Cui DX
Tue May 16 00:00:00 EDT 2017
TRPC5 channel modulates endothelial cells senescence.
European journal of pharmacology
Li Z,Guo G,Wang H,Si X,Zhou G,Xiong Y,Li S,Dai R,Yang C
Fri May 05 00:00:00 EDT 2017
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Oncotarget
Ma H,Li L,Dou G,Wang C,Li J,He H,Wu M,Qi H
Tue Apr 25 00:00:00 EDT 2017
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
EMBO reports
Shen Y,Liu S,Fan J,Jin Y,Tian B,Zheng X,Fu H
Sat Apr 01 00:00:00 EDT 2017
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Cell proliferation
Zhou Z,Yin Y,Chang Q,Sun G,Lin J,Dai Y
Sat Apr 01 00:00:00 EDT 2017
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Biochemical and biophysical research communications
Lei K,Liang X,Gao Y,Xu B,Xu Y,Li Y,Tao Y,Shi W,Liu J
Sat Mar 11 00:00:00 EST 2017
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
The international journal of biochemistry & cell biology
Yin Y,Zhou Z,Liu W,Chang Q,Sun G,Dai Y
Wed Mar 01 00:00:00 EST 2017
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.
American journal of physiology. Lung cellular and molecular physiology
Cui H,Ge J,Xie N,Banerjee S,Zhou Y,Liu RM,Thannickal VJ,Liu G
Wed Mar 01 00:00:00 EST 2017
RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line.
Oncology research
Zhou C,Zhang P,Xu GC,Wu DM,Liu RY,Zeng Q,Wang CT
Mon Feb 06 00:00:00 EST 2017
miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence.
American journal of respiratory cell and molecular biology
Cui H,Ge J,Xie N,Banerjee S,Zhou Y,Antony VB,Thannickal VJ,Liu G
Wed Feb 01 00:00:00 EST 2017
ISG15 inhibits cancer cell growth and promotes apoptosis.
International journal of molecular medicine
Zhou MJ,Chen FZ,Chen HC,Wan XX,Zhou X,Fang Q,Zhang DZ
Wed Feb 01 00:00:00 EST 2017
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Toxicology letters
Yang J,Qiao L,Zeng Z,Wang J,Zhu T,Wei J,Wu M,Ye S,Huang X,Ma D,Liu R,Gao Q
Wed Jan 04 00:00:00 EST 2017
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Journal of molecular medicine (Berlin, Germany)
Zu G,Yao J,Ji A,Ning S,Luo F,Li Z,Feng D,Rui Y,Li Y,Wang G,Tian X
Sun Jan 01 00:00:00 EST 2017
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Tang Q,Ji F,Sun W,Wang J,Guo J,Guo L,Li Y,Bao Y
Thu Dec 15 00:00:00 EST 2016
A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.
The Journal of biological chemistry
Xia L,Wang XR,Wang XL,Liu SH,Ding XW,Chen GQ,Lu Y
Fri Dec 09 00:00:00 EST 2016
Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1.
Taiwanese journal of obstetrics & gynecology
Zhou Y,Wang K,Zhen S,Wang R,Luo W
Thu Dec 01 00:00:00 EST 2016
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.
Scientific reports
Fischer A,Warscheid B,Weber W,Radziwill G
Wed Nov 30 00:00:00 EST 2016
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Cell cycle (Georgetown, Tex.)
Yuan S,Wen J,Cheng J,Shen W,Zhou S,Yan W,Shen L,Luo A,Wang S
Tue Nov 01 00:00:00 EDT 2016
Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma.
Oncotarget
Zhan L,Cao H,Wang G,Lyu Y,Sun X,An J,Wu Z,Huang Q,Liu B,Xing J
Tue Oct 04 00:00:00 EDT 2016
Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression.
Scientific reports
Ye J,Yao Y,Song Q,Li S,Hu Z,Yu Y,Hu C,Da X,Li H,Chen Q,Wang QK
Tue Oct 04 00:00:00 EDT 2016
Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression.
Scientific reports
Ye J,Yao Y,Song Q,Li S,Hu Z,Yu Y,Hu C,Da X,Li H,Chen Q,Wang QK
Tue Oct 04 00:00:00 EDT 2016
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Oncology letters
Xu Y,Wu D,Fan Y,Li P,Du H,Shi J,Wang D,Zhou X
Sat Oct 01 00:00:00 EDT 2016
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Nutrients
Wang Y,Zhang XN,Xie WH,Zheng YX,Cao JP,Cao PR,Chen QJ,Li X,Sun CD
Tue Sep 27 00:00:00 EDT 2016
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Nutrients
Wang Y,Zhang XN,Xie WH,Zheng YX,Cao JP,Cao PR,Chen QJ,Li X,Sun CD
Tue Sep 27 00:00:00 EDT 2016
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
Scientific reports
Dia VP,Krishnan HB
Thu Sep 15 00:00:00 EDT 2016
Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival.
The Journal of biological chemistry
Liao Y,Chu HP,Hu Z,Merkin JJ,Chen J,Liu Z,Degenhardt K,White E,Ryazanov AG
Fri Sep 09 00:00:00 EDT 2016
Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats.
Scientific reports
Wang WJ,Cai GY,Ning YC,Cui J,Hong Q,Bai XY,Xu XM,Bu R,Sun XF,Chen XM
Tue Jul 26 00:00:00 EDT 2016
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Oncology reports
Wang Z,Tang F,Hu P,Wang Y,Gong J,Sun S,Xie C
Fri Jul 01 00:00:00 EDT 2016
Macrophage migration inhibitory factor in the regulation of myoblast proliferation and differentiation.
Bioscience, biotechnology, and biochemistry
Wen F,Zheng J,Yu J,Gao M,Gao S,Zhou Y,Liu J,Yang Z
Fri Jul 01 00:00:00 EDT 2016
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Antioxidants & redox signaling
Wang G,Yao J,Li Z,Zu G,Feng D,Shan W,Li Y,Hu Y,Zhao Y,Tian X
Fri Jun 10 00:00:00 EDT 2016
Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.
PloS one
Cao L,Ding J,Dong L,Zhao J,Su J,Wang L,Sui Y,Zhao T,Wang F,Jin J,Cai Y
Tue May 17 00:00:00 EDT 2016
The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker.
Oncotarget
Chen S,Sun KX,Liu BL,Zong ZH,Zhao Y
Tue May 10 00:00:00 EDT 2016
Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress.
Oncotarget
Dai Y,Wang L,Tang J,Cao P,Luo Z,Sun J,Kiflu A,Sai B,Zhang M,Wang F,Li G,Xiang J
Tue May 03 00:00:00 EDT 2016
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
Oncotarget
Feng T,Shao F,Wu Q,Zhang X,Xu D,Qian K,Xie Y,Wang S,Xu N,Wang Y,Qi C
Tue Mar 29 00:00:00 EDT 2016
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
Scientific reports
Xu X,Pang J,Chen Y,Bucala R,Zhang Y,Ren J
Fri Mar 04 00:00:00 EST 2016
Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.
PloS one
Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X
Thu Feb 04 00:00:00 EST 2016
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Oncotarget
Chen P,Yu N,Zhang Z,Zhang P,Yang Y,Wu N,Xu L,Zhang J,Ge J,Yu K,Zhuang J
Tue Feb 02 00:00:00 EST 2016
MiR-512-5p induces apoptosis and inhibits glycolysis by targeting p21 in non-small cell lung cancer cells.
International journal of oncology
Chu K,Gao G,Yang X,Ren S,Li Y,Wu H,Huang Y,Zhou C
Mon Feb 01 00:00:00 EST 2016
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Deng S,Tang S,Dai C,Zhou Y,Yang X,Li D,Xiao X
Mon Feb 01 00:00:00 EST 2016
Induction of Apoptosis in Human Leukemic Cell Lines by Diallyl Disulfide via Modulation of EGFR/ERK/PKM2 Signaling Pathways.
Asian Pacific journal of cancer prevention : APJCP
Luo N,Zhao LC,Shi QQ,Feng ZQ,Chen DL,Li J
Tue Jan 26 00:00:00 EST 2016
A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells.
Cancer chemotherapy and pharmacology
Zhen N,Yang Q,Wu Q,Zhu X,Wang Y,Sun F,Mei W,Yu Y
Fri Jan 01 00:00:00 EST 2016
Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549.
Asian Pacific journal of cancer prevention : APJCP
Wu DM,Zhang P,Xu GC,Tong AP,Zhou C,Lang JY,Wang CT
Tue Dec 08 00:00:00 EST 2015
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
Experimental biology and medicine (Maywood, N.J.)
Sun S,Cheng B,Sun PG,Wu XH,Wu QQ,He P
Tue Dec 01 00:00:00 EST 2015
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Digestive diseases and sciences
Wang X,Han L,Zhang J,Xia Q
Thu Oct 01 00:00:00 EDT 2015
MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3.
Oncotarget
Fan Z,Cui H,Xu X,Lin Z,Zhang X,Kang L,Han B,Meng J,Yan Z,Yan X,Jiao S
Tue Sep 22 00:00:00 EDT 2015
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
The Journal of biological chemistry
Li H,Liu Q,Wang Z,Fang R,Shen Y,Cai X,Gao Y,Li Y,Zhang X,Ye L
Fri Sep 11 00:00:00 EDT 2015
Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy.
Biochemical and biophysical research communications
Zhu L,Dong C,Sun C,Ma R,Yang D,Zhu H,Xu J
Fri Aug 21 00:00:00 EDT 2015
Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.
The Journal of biological chemistry
Liu M,Chen Y,Zhang L,Wang Q,Ma X,Li X,Xiang R,Zhu Y,Qin S,Yu Y,Jiang XC,Duan Y,Han J
Fri Jun 05 00:00:00 EDT 2015
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Aging cell
Hua Y,Robinson TJ,Cao Y,Shi GP,Ren J,Nair S
Mon Jun 01 00:00:00 EDT 2015
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
Oncotarget
Liu T,Men Q,Wu G,Yu C,Huang Z,Liu X,Li W
Fri Apr 10 00:00:00 EDT 2015
Potent effects of dioscin against liver fibrosis.
Scientific reports
Zhang X,Han X,Yin L,Xu L,Qi Y,Xu Y,Sun H,Lin Y,Liu K,Peng J
Wed Apr 08 00:00:00 EDT 2015
Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects.
Developmental cell
Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F
Mon Apr 06 00:00:00 EDT 2015
Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.
PloS one
Storbeck M,Hupperich K,Gaspar JA,Meganathan K,Martínez Carrera L,Wirth R,Sachinidis A,Wirth B
Sat Jan 10 00:00:00 EST 2015
Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma.
Journal of experimental & clinical cancer research : CR
Lv Z,Wu X,Cao W,Shen Z,Wang L,Xie F,Zhang J,Ji T,Yan M,Chen W
Thu Dec 18 00:00:00 EST 2014
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Metallomics : integrated biometal science
Wu Q,He J,Mei W,Zhang Z,Wu X,Sun F
Mon Dec 01 00:00:00 EST 2014
The involvement of CXCR7 in modulating the progression of papillary thyroid carcinoma.
The Journal of surgical research
Liu Z,Yang L,Teng X,Zhang H,Guan H
Wed Oct 01 00:00:00 EDT 2014
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
International journal of oncology
Ning Z,Wang A,Liang J,Xie Y,Liu J,Feng L,Yan Q,Wang Z
Wed Oct 01 00:00:00 EDT 2014
miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.
Molecular cancer
Jung HM,Phillips BL,Chan EK
Tue Apr 08 00:00:00 EDT 2014
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Cancer letters
Yang CF,Peng LX,Huang TJ,Yang GD,Chu QQ,Liang YY,Cao X,Xie P,Zheng LS,Huang HB,Cai MD,Huang JL,Liu RY,Zhu ZY,Qian CN,Huang BJ
Fri Mar 28 00:00:00 EDT 2014
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
Oncology reports
Sun Q,Wang R,Wang Y,Luo J,Wang P,Cheng B
Sat Feb 01 00:00:00 EST 2014
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Journal of hepatology
Xu X,Hueckstaedt LK,Ren J
Thu Aug 01 00:00:00 EDT 2013
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Journal of hepatology
Xu X,Hueckstaedt LK,Ren J
Thu Aug 01 00:00:00 EDT 2013
Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Cun B,Song X,Jia R,Wang H,Zhao X,Liu B,Ge S,Fan X
Sat Jun 01 00:00:00 EDT 2013
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Cell reports
Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D
Thu May 30 00:00:00 EDT 2013
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Oncogene
Zhang J,Sun Q,Zhang Z,Ge S,Han ZG,Chen WT
Thu Jan 03 00:00:00 EST 2013
Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expression in SMMC-7721 hepatocellular carcinoma cells.
Oncology letters
Yao Y,Li L,Zhang H,Jia R,Liu B,Zhao X,Zhang L,Qian G,Fan X,Ge S
Sun Jul 01 00:00:00 EDT 2012
protein-binding activity modulator
