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Product Details
28207-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
P2RX7 Fusion Protein Ag27700
Conjugate
Form
Liquid
Concentration
300 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A
Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R
UniProt ID: (Human) Q99572, (Mouse) Q9Z1M0
Entrez Gene ID: (Human) 5027, (Mouse) 18439
activation of MAPK activity
cell morphogenesis
phagolysosome assembly
positive regulation of T cell mediated cytotoxicity
regulation of sodium ion transport
protein phosphorylation
membrane protein ectodomain proteolysis
phospholipid transfer to membrane
membrane budding
inflammatory response
mitochondrion organization
cell surface receptor signaling pathway
blood coagulation
response to mechanical stimulus
response to zinc ion
positive regulation of calcium ion transport into cytosol
positive regulation of gene expression
positive regulation of glutamate secretion
positive regulation of gamma-aminobutyric acid secretion
synaptic vesicle exocytosis
protein processing
phospholipid scrambling
sensory perception of pain
cytolysis
positive regulation of bone mineralization
cellular response to extracellular stimulus
bleb assembly
positive regulation of prostaglandin secretion
response to lipopolysaccharide
positive regulation of interleukin-6 production
collagen metabolic process
response to ATP
response to fluid shear stress
positive regulation of ion transmembrane transport
purinergic nucleotide receptor signaling pathway
T cell proliferation
response to drug
T cell homeostasis
NAD transport
negative regulation of MAPK cascade
multicellular organismal protein catabolic process
phospholipid translocation
negative regulation of bone resorption
negative regulation of cell volume
positive regulation of glycolytic process
positive regulation of cytolysis
ceramide biosynthetic process
pore complex assembly
skeletal system morphogenesis
homeostasis of number of cells within a tissue
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
defense response to Gram-positive bacterium
release of sequestered calcium ion into cytosol
protein oligomerization
positive regulation of cytoskeleton organization
response to calcium ion
response to electrical stimulus
regulation of killing of cells of other organism
membrane depolarization
positive regulation of mitochondrial depolarization
positive regulation of lymphocyte apoptotic process
cellular response to dsRNA
reactive oxygen species metabolic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
positive regulation of bleb assembly
positive regulation of protein phosphorylation
transport
ion transport
cation transport
calcium ion transport
cell volume homeostasis
plasma membrane organization
response to bacterium
response to organic substance
gene expression
programmed cell death
response to organic cyclic compound
positive regulation of interleukin-1 beta production
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
positive regulation of ossification
positive regulation of protein secretion
positive regulation of cytokine secretion
cellular response to organic cyclic compound
cation transmembrane transport
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