|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues G(364) L Q E N M R T S(372) of rat P2X1.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Immunohistochemistry (IHC)||See 1 publications below|
PA1-24622 detects P2X1 from rat samples. PA1-24622 is expected to cross react with human (100% conserved) and mouse (100% conserved) due to sequence homology.
PA1-24622 has been successfully used in immunohistochemistry (frozen) and immunocytochemistry procedures.
The PA1-24622 immunogen is a synthetic peptide corresponding to residues G(364) L Q E N M R T S(372) of rat P2X1.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
The involvement of P2X₁ receptor in pyramidal cell degeneration in the rat hippocampus after trimethyltin administration.
PA1-24622 was used in immunohistochemistry to characterize the expression of the P2X(1) receptor in the hippocampus
|Shirakawa T,Nakano K,Hachiya N,Kato N,Kaneko K||Neuroscience research (71:396)||2011|
ATP receptor; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; programmed cell death 3; purinergic receptor P2X, ligand gated ion channel, 1; purinergic receptor P2X, ligand-gated ion channel, 1; purinergic receptor P2X1; RP-2 protein
AI323649; BB122383; P2RX1; P2x; P2X1; P2XMR; Pdcd3; RP-2