|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues G(364) L Q E N M R T S(372) of rat P2X1.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA1-24622 detects P2X1 from rat samples. PA1-24622 is expected to cross react with human (100% conserved) and mouse (100% conserved) due to sequence homology.
PA1-24622 has been successfully used in immunohistochemistry (frozen) and immunocytochemistry procedures.
The PA1-24622 immunogen is a synthetic peptide corresponding to residues G(364) L Q E N M R T S(372) of rat P2X1.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The involvement of P2X¿ receptor in pyramidal cell degeneration in the rat hippocampus after trimethyltin administration.
PA1-24622 was used in immunohistochemistry to characterize the expression of the P2X(1) receptor in the hippocampus
|Shirakawa T,Nakano K,Hachiya N,Kato N,Kaneko K||Neuroscience research (71:396)||2011|