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Alomone Labs, LTD
P2X2 Receptor Polyclonal Antibody
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FIGURE: 1 / 3
P2X2 Receptor Antibody (APR-003-200UL) in IHC
Expression of P2X2 receptor in rat hippocampus - Immunohistochemical staining of rat hippocampus with Anti-P2X2Receptor Antibody (#APR-003). P2X2 receptor (green) appears in the apical dendrites (arrows) that extend into the striatum radiatum (asterisk). DAPI is used as the counterstain (blue).
Product Details
APR-003-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)SQQDSTSTDPKGLAQL, corresponding to amino acid residues 457-472 of rat P2X2 receptor, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; MGC129601; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2
Gene Aliases: DFNA41; P2RX2; P2X2; P2X2a
UniProt ID: (Human) Q9UBL9, (Rat) P49653, (Mouse) Q8K3P1
Entrez Gene ID: (Human) 22953, (Rat) 114115, (Mouse) 231602
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ATP binding
ligand-gated ion channel activity
identical protein binding
ion channel activity
copper ion binding
protein binding
drug binding
zinc ion binding
nickel cation binding
phosphatidylinositol binding
mercury ion binding
cadmium ion binding
cobalt ion binding
ligand-gated ion channel
response to hypoxia
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
neuromuscular synaptic transmission
neuromuscular junction development
blood coagulation
sensory perception of sound
response to carbohydrate
positive regulation of calcium ion transport into cytosol
urinary bladder smooth muscle contraction
peristalsis
response to ATP
purinergic nucleotide receptor signaling pathway
behavioral response to pain
skeletal muscle fiber development
positive regulation of calcium-mediated signaling
sensory perception of taste
protein homooligomerization
cation transmembrane transport
cation transport
chemical synaptic transmission
response to organic substance
neuronal action potential
ion transmembrane transport
protein heterooligomerization
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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