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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 136 and 395 of Human P2X3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30894 targets P2X3 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30894 immunogen is recombinant fragment corresponding to a region within amino acids 136 and 395 of Human P2X3.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ATP receptor; P2X purinoceptor 3; P2X receptor; P2X receptor, subunit 3; P2X3; p2xr3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3; purinergic receptor P2X3; purinoceptor P2X3; subunit 3