Peptide sequence: VQLLILAYVI GWVFVWEKGY QETDSVVSSV TTKVKGVAVT NTSKLGFRIW
Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 86%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 86%
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
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Protein Aliases: ATP receptor; ATP-gated cation channel protein; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinoceptor P2X4
Gene Aliases: P2RX4; P2X4; P2X4R
UniProt ID: (Human) Q99571
Entrez Gene ID: (Human) 5025