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Invitrogen
P2X4 Polyclonal Antibody
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Product Details
PA5-83466
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human P2RX4. Recombinant protein control fragment (Product #RP-97746).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YCMKKRLYYR EKKYKYVEDY EQGLASELDQ
Highest antigen sequence indentity to the following orthologs: Rat - 77%, Mouse - 83%.
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP receptor; ATP-gated cation channel protein; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinoceptor P2X4
Gene Aliases: P2RX4; P2X4; P2X4R
UniProt ID: (Human) Q99571
Entrez Gene ID: (Human) 5025
tissue homeostasis
regulation of sodium ion transport
transport
signal transduction
blood coagulation
regulation of blood pressure
positive regulation of calcium ion transport into cytosol
negative regulation of cardiac muscle hypertrophy
neuronal action potential
sensory perception of pain
positive regulation of prostaglandin secretion
response to ATP
ion transmembrane transport
response to fluid shear stress
purinergic nucleotide receptor signaling pathway
endothelial cell activation
positive regulation of nitric oxide biosynthetic process
positive regulation of calcium-mediated signaling
protein homooligomerization
membrane depolarization
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
relaxation of cardiac muscle
cellular response to ATP
apoptotic signaling pathway
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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