Immunogen sequence: QETDSVVSSV TTKVKGVAVT NTSKLGFRIW DVADYVIPAQ EENSLFVMTN VILTMNQTQG LCPEIPDATT VCKSDASCTA GSAGTHSNGV STGRCVAFNG SVKTCEVAAW CPVEDDTHVP QPAFLKAAEN FTLLVKNNIW YPKFNFSKRN ILPNITTTYL KSCIYDAKTD PFCPIFRLGK IVENAGHSFQ DMAVEGGIMG IQVNWDCNLD RAASLCLPRY SFRRLDTRDV EHNVSPGYNF RFAKYYRDLA GNEQRTLIKA YGIRFDIIVF GKAGKFDIIP TMIN; Positive Samples: 22Rv1, Mouse kidney, Mouse lung; Cellular Location: Membrane, Multi-pass membrane protein
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
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Protein Aliases: ATP receptor; ATP-gated cation channel protein; ionotropic purinergic receptor; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinergic receptor P2x4 subunit variant e; purinoceptor P2X4
Gene Aliases: AI504491; AW555605; D5Ertd444e; P2RX4; P2X4; P2X4R
UniProt ID: (Human) Q99571