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P2X5b Polyclonal Antibody
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Product Details
BS-12109R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human P2X5b, amino acids 261-360.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; ATP receptor subunit; ionotropic ATP receptor P2X5; lymphoid-restricted histocompatibility antigen-1; P2RX5; P2X purinoceptor 5; P2X5; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 5; purinergic receptor P2X5-2; unnamed protein product
Gene Aliases: LRH-1; P2RX5; P2X5; P2X5FL; P2X5R
UniProt ID: (Human) Q93086, (Mouse) Q91VE2, (Rat) P51578
Entrez Gene ID: (Human) 5026, (Mouse) 94045, (Rat) 113995
purinergic nucleotide receptor activity
transmembrane signaling receptor activity
extracellular ATP-gated cation channel activity
ion channel activity
voltage-gated ion channel activity
ATP binding
channel activity
ATP-gated ion channel activity
identical protein binding
ligand-gated monoatomic anion channel activity
GTP binding
drug binding
zinc ion binding
ligand-gated ion channel
ion transport
chloride transport
signal transduction
nervous system development
response to pH
response to zinc ion
positive regulation of calcium ion transport into cytosol
response to ATP
ion transmembrane transport
purinergic nucleotide receptor signaling pathway
osteoclast maturation
regulation of skeletal muscle tissue regeneration
positive regulation of calcium-mediated signaling
response to calcium ion
excitatory postsynaptic potential
calcium ion transmembrane transport
cation transmembrane transport
anion transmembrane transport
positive regulation of calcium ion import across plasma membrane
cell surface receptor signaling pathway
neuronal action potential
protein homooligomerization
mitophagy in response to mitochondrial depolarization
cation transport
skeletal muscle tissue growth
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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