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Product Details
BS-12109R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human P2X5b, amino acids 261-360.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; ATP receptor subunit; ionotropic ATP receptor P2X5; lymphoid-restricted histocompatibility antigen-1; P2X purinoceptor 5; P2X5; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 5; purinergic receptor P2X, ligand-gated ion channel, 5; purinergic receptor P2X5-2
Gene Aliases: LRH-1; P2RX5; P2X5; P2X5FL; P2X5R
UniProt ID: (Human) Q93086, (Mouse) Q91VE2, (Rat) P51578
Entrez Gene ID: (Human) 5026, (Mouse) 94045, (Rat) 113995
transport
signal transduction
nervous system development
blood coagulation
positive regulation of calcium ion transport into cytosol
response to ATP
purinergic nucleotide receptor signaling pathway
positive regulation of calcium-mediated signaling
cation transmembrane transport
mitophagy in response to mitochondrial depolarization
cell surface receptor signaling pathway
neuronal action potential
regulation of skeletal muscle tissue regeneration
protein homooligomerization
cation transport
skeletal muscle tissue growth
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