Positive controls: Jurkat cell lysate, K562 cell lysate, rat skeletal muscle tissue, rat brain tissue, mouse skeletal muscle tissue, mouse heart tissue, SH-SY5Y.
P2rx6 encodes receptors that are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each P2rx6 receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. The protein encoded by the P2rx6 gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. The P2rx6 gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants of P2rx6.
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Protein Aliases: ATP receptor; P2X purinoceptor 6; P2X6; P2X6 receptor; P2XM; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 6; purinergic receptor P2X, ligand-gated ion channel, 6; Purinergic receptor P2X-like 1; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X-like 1, orphan receptor; purinergic receptor P2X6; purinoceptor P2X6; purinoreceptor P2X6; skeletal muscle-expressed P2X
Gene Aliases: P2RX6; P2RXL1; P2X6; P2XM; Rnap2x6