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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • P2X7 Antibodies

          Invitrogen

          P2X7 Polyclonal Antibody

          3 Published Figures
          1 Reference
          View all (28) P2X7 antibodies
          Datasheet
          Protocols
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          Tech Support

          Cite P2X7 Polyclonal Antibody

          Datasheet
          Protocols
          Questions & Answers
          Tech Support
          • Antibody Testing Data (2)
          • Published Figures (3)
          P2X7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          P2X7 Antibody (PA5-19165) in IHC (P)

          Immunohistochemical analysis of P2X7 in paraffin embedded human cortex using a P2X7 polyclonal antibody (Product #PA5-19165) at a concentration of 3.8 µg/mL. Steamed antigen retrieval was performed with pH 6 buffered citrate. Samples were then stained with alkaline phosphatase. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-19165

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-3 µg/mL
          -

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          3-6 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Published species

          Human

          Host/Isotype

          Goat / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide sequence (YETNKVTRIQSMNY) corresponding to the N-terminus amino acids of P2RX7
          View immunogen

          Conjugate

          Unconjugated

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          TBS, pH 7.3, with 0.5% BSA

          Contains

          0.02% sodium azide

          Storage conditions

          -20° C, Avoid Freeze/Thaw Cycles

          RRID

          AB_10979297

          Product Specific Information

          This antibody is predicted to react with canine, mouse and rat based on sequence homology.

          Target Information

          The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A

          View more View less

          Gene Aliases: P2RX7; P2X7

          View more View less

          UniProt ID: (Human) Q99572

          View more View less

          Entrez Gene ID: (Human) 5027

          View more View less

          Molecular Function: ligand-gated ion channel

          Function(s)
          activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane membrane budding inflammatory response mitochondrion organization cell surface receptor signaling pathway blood coagulation response to mechanical stimulus response to zinc ion positive regulation of calcium ion transport into cytosol positive regulation of gene expression positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis NAD transport negative regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus regulation of killing of cells of other organism membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway positive regulation of bleb assembly
          Process(es)
          lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity
          It has to be done as per old AB suggested Products section.
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