PA5-29274 targets P2X7 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29274 immunogen is recombinant protein fragment corresponding to a region within amino acids 29 and 263 of Human P2X7.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.
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Protein Aliases: ATP receptor; P2X purinoceptor 7; P2X7; P2X7 receptor; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A
Gene Aliases: P2RX7; P2X7
UniProt ID: (Human) Q99572
Entrez Gene ID: (Human) 5027