Invitrogen

P2X7 Polyclonal Antibody

2 References
View all (23) P2X7 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-32201

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide encompassing a sequence within the Intracellular domain of rat P2rx7. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2549674

Product Specific Information

Recommended positive controls: mouse brain.

Predicted reactivity: Rat (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X7

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Gene Aliases: AI467586; P2rx7; P2X(7); P2x7; P2X7R

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UniProt ID: (Rat) Q64663, (Mouse) Q9Z1M0

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Entrez Gene ID: (Rat) 29665, (Mouse) 18439

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Function(s)
magnesium ion binding lipopolysaccharide binding purinergic nucleotide receptor activity receptor activity extracellular ATP-gated cation channel activity receptor binding copper ion binding protein binding ATP binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity ligand-gated ion channel
Process(es)
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization cell surface receptor signaling pathway response to mechanical stimulus response to bacterium response to organic substance response to zinc ion gene expression positive regulation of calcium ion transport into cytosol programmed cell death positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound organic cation transport synaptic vesicle exocytosis protein processing neuronal action potential sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis positive regulation of apoptotic process positive regulation of catalytic activity NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation positive regulation of ossification negative regulation of bone resorption positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to organic cyclic compound reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway cation transmembrane transport transport ion transport positive regulation of gene expression phospholipid scrambling positive regulation of ion transmembrane transport negative regulation of cell volume positive regulation of glycolytic process cellular response to dsRNA positive regulation of bleb assembly
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