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Invitrogen

P2X7 Polyclonal Antibody

View all (29) P2X7 antibodies

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Product Details

PA5-34068

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

10-20 µg/mL
-
Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 16 amino acid peptide from internal region of human P2RX7 / P2X7.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551423

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%) Marmoset, Pig (88%) Mouse, Horse (81%).

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP agonist non-selective cationic pore-forming protein; ATP receptor; ligand gated ion channel; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 receptor; P2X7; cervical cancer susceptibility protein; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purnergic receptor P2X 7; unnamed protein product

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Gene Aliases: P2RX7; P2X7

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UniProt ID: (Human) Q99572

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Entrez Gene ID: (Human) 5027

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Function(s)
nucleotide binding lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding ion channel activity potassium channel activity sodium channel activity protein binding ATP binding GTP binding channel activity signaling receptor activity identical protein binding metal ion binding
Process(es)
MAPK cascade cell morphogenesis phagolysosome assembly T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport response to ischemia membrane protein ectodomain proteolysis phospholipid transfer to membrane ion transport cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization cell surface receptor signaling pathway protein secretion response to xenobiotic stimulus response to mechanical stimulus response to bacterium response to zinc ion gene expression positive regulation of calcium ion transport into cytosol positive regulation of gene expression programmed cell death glutamate secretion positive regulation of glutamate secretion gamma-aminobutyric acid secretion positive regulation of gamma-aminobutyric acid secretion organophosphate ester transport synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain calcium-mediated signaling protein catabolic process positive regulation of bone mineralization bleb assembly positive regulation of prostaglandin secretion prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP ion transmembrane transport response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway sodium ion transmembrane transport T cell proliferation T cell homeostasis positive regulation of apoptotic process NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade phospholipid translocation positive regulation of ossification negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion defense response to Gram-positive bacterium regulation of transport positive regulation of cellular component organization release of sequestered calcium ion into cytosol positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus establishment of localization in cell mitochondrial depolarization membrane depolarization positive regulation of mitochondrial depolarization excitatory postsynaptic potential positive regulation of macrophage cytokine production protein homotrimerization lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process T cell apoptotic process positive regulation of T cell apoptotic process calcium ion transmembrane transport cellular response to ATP cellular response to dsRNA potassium ion transmembrane transport reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway cation transmembrane transport positive regulation of NLRP3 inflammasome complex assembly positive regulation of bleb assembly
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