Immunogen sequence: SDKLYQRKEP VISSVHTKVK GIAEVKEEIV ENGVKKLVHS VFDTADYTFP LQGNSFFVMT NFLKTEGQEQ RLCPEYPTRR TLCSSDRGCK KGWMDPQSKG IQTGRCVVYE GNQKTCEVSA WCPIEAVEEA PRPALLNSAE NFTVLIKNNI DFPGHNYTTR NILPGLNITC TFHKTQNPQC PIFRLGDIFR ETGDNFSDVA IQGGIMGIEI YWDCNLDRWF HHCRPKYSFR RLDDKTTNVS LYPGYNFRYA KYYKENNVEK RTLIKVFGIR FDILVFGTGG KFDIIQLV; Positive Samples: A375, HT-29, U-251MG, LO2, Mouse heart, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.
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Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A
Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R