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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • P2X7 Antibodies

          Alomone Labs, LTD

          P2X7 Receptor Polyclonal Antibody

          View all (23) P2X7 antibodies

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          Cite P2X7 Receptor Polyclonal Antibody

          • Antibody Testing Data (2)
          P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          P2X7 Receptor Antibody (APR-004-200UL) in IHC (P)

          Expression of P2X7 Receptorin rat pancreas - Immunohistochemical staining of rat paraffin-embedded endocrine and exocrine pancreas sections using Anti-P2X7 Receptor Antibody (#APR-004), (1:50), followed by goat Anti-rabbit-AlexaFluor-555-secondary Antibody (1:500), (red). Staining is highly specific for endocrine cells of theIsle of Langerhans.Hoechst 33342 is used as the counterstain (blue). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          P2X7 Receptor Antibody in Western Blot (WB)
          P2X7 Receptor Polyclonal Antibody

          Product Details

          APR-004-200UL

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:200
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          (C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 receptor, Intracellular, C-terminus
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Concentration

          0.6 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 1% BSA

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

          Target Information

          The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A

          View more View less

          Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R

          View more View less

          UniProt ID: (Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

          View more View less

          Entrez Gene ID: (Human) 5027, (Rat) 29665, (Mouse) 18439

          View more View less

          Function(s)
          lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity magnesium ion binding receptor activity copper ion binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity ligand-gated ion channel
          Process(es)
          activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane membrane budding inflammatory response mitochondrion organization cell surface receptor signaling pathway blood coagulation response to mechanical stimulus response to zinc ion positive regulation of calcium ion transport into cytosol positive regulation of gene expression positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis NAD transport negative regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus regulation of killing of cells of other organism membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway positive regulation of bleb assembly positive regulation of protein phosphorylation cation transport calcium ion transport cell volume homeostasis plasma membrane organization response to bacterium response to organic substance gene expression programmed cell death response to organic cyclic compound organic cation transport neuronal action potential positive regulation of interleukin-1 beta production positive regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of ossification positive regulation of protein secretion positive regulation of cytokine secretion cellular response to organic cyclic compound cation transmembrane transport transport ion transport
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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