Alomone Labs, LTD

P2X7 Receptor (extracellular) Polyclonal Antibody, Atto™ 488

View all (28) P2X7 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

APR-008-AG-50UL

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:25
-

Flow Cytometry (Flow)

10 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KKGWMDPQSKGIQTGRC, corresponding to amino acid residues 136-152 of mouse P2X7 receptor, Extracellular loop
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Conjugate

Atto™ 488 Atto™ 488 Atto™ 488

Excitation/Emission Max

501/523 nm

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A

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Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R

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UniProt ID: (Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

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Entrez Gene ID: (Human) 5027, (Rat) 29665, (Mouse) 18439

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Function(s)
lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity magnesium ion binding receptor activity copper ion binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity ligand-gated ion channel
Process(es)
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane membrane budding inflammatory response mitochondrion organization cell surface receptor signaling pathway blood coagulation response to mechanical stimulus response to zinc ion positive regulation of calcium ion transport into cytosol positive regulation of gene expression positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis NAD transport negative regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus regulation of killing of cells of other organism membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway positive regulation of bleb assembly positive regulation of protein phosphorylation cation transport calcium ion transport cell volume homeostasis plasma membrane organization response to bacterium response to organic substance gene expression programmed cell death response to organic cyclic compound organic cation transport neuronal action potential positive regulation of interleukin-1 beta production positive regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of ossification positive regulation of protein secretion positive regulation of cytokine secretion cellular response to organic cyclic compound cation transmembrane transport transport ion transport
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