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Alomone Labs, LTD
P2Y1 Receptor (extracellular) Polyclonal Antibody, FITC
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FIGURE: 1 / 3
P2Y1 Receptor (extracellular) Antibody (APR-021-F-50UL) in Flow
Cell surface detection of P2Y1Receptor by direct flow cytometry in live intact human MEG-01 megakaryoblastic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-P2Y1Receptor (extracellular)-FITC Antibody (APR-021-F), 2.5 µg.
Product Details
APR-021-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SDEYLRSYFIYSMC, corresponding to amino acid residues 207-220 of human P2RY1, Extracellular, 2nd loop
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
P2Y1 is a Purinergic Receptor that causes a change in platelet shape and potentially leads to platelet aggregation by binding ADP, which results in the mobilization of intracellular calcium ions via activation of phospholipase C. This receptor also mediates the release of the relaxing factor nitric oxide and may be involved in the modulation of neuronal signal transmission. P2Y1 has been reported to be expressed in tissues throughout the body, particularly brain. ESTs have been isolated from human embryo, lung, and placenta libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP receptor; ATP receptor; P2 purinoceptor subtype Y1; P2 purinoreceptor subclass 2Y; P2Y ATP receptor 1; P2Y purinoceptor 1; p2y-1-r; P2Y1; P2Y1 receptor; p2y1r; platelet ADP receptor; Purinergic receptor; purinergic receptor P2Y, G-protein coupled, 1; Purinoceptor p2y1; Purinoceptor p2yr1
Gene Aliases: P2RY1; P2y; P2Y1
UniProt ID: (Human) P47900, (Rat) P49651, (Mouse) P49650
Entrez Gene ID: (Human) 5028, (Rat) 25265, (Mouse) 18441
receptor activity
protein binding
ATP binding
A1 adenosine receptor binding
ADP binding
G-protein coupled purinergic nucleotide receptor activity
ATP-activated adenosine receptor activity
ADP-activated adenosine receptor activity
protein heterodimerization activity
scaffold protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled receptor
positive regulation of protein phosphorylation
adenosine receptor signaling pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
aging
glial cell migration
response to mechanical stimulus
regulation of receptor activity
negative regulation of norepinephrine secretion
sensory perception of pain
signal transduction involved in regulation of gene expression
platelet activation
positive regulation of inositol trisphosphate biosynthetic process
G-protein coupled purinergic nucleotide receptor signaling pathway
regulation of vasodilation
eating behavior
positive regulation of ion transport
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
negative regulation of binding
positive regulation of penile erection
positive regulation of ERK1 and ERK2 cascade
response to growth factor
cellular response to organic cyclic compound
protein localization to plasma membrane
relaxation of muscle
wound healing
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
signal transduction
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