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Alomone Labs, LTD
P2Y6 Receptor Polyclonal Antibody
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FIGURE: 1 / 2
P2Y6 Receptor Antibody (APR-011-200UL) in IHC (F)
Expression ofP2Y6inrat cortex. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-P2Y6 Receptor Antibody &(8)239; (#APR-011), (1:600), followed by donkey Anti-rabbit-biotin and Streptavidin-Cy3. A. P2Y6 immunoreactivity (red) appears in cortical neurons (horizontal arrows) and astrocytes (vertical arrows). B. Pre-incubation of the Antibody with P2Y6 Receptor Blocking Peptide... View More
Product Details
APR-011-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CQPHDLLQKLTAKWQRQRV, corresponding to amino acid residues 311-328 of rat P2Y6 receptor, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.75 mg/mL
Amount
150 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
P2Y6 belongs to the family of G protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. P2Y6 expression has been documented in various blood cells, bone marrow, brain, colon, heart, kidney, ovary, placenta, spleen and thymus. ESTs have been isolated from cervix, embryo, eye, kidney, liver/spleen, placenta, and vessel libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-coupled nucleotide receptor; G-protein coupled receptor; long splice variant; MGC15335; P2 purinoceptor; P2Y ATP receptor 6; P2Y purinoceptor 6; p2y3 and chick; p2y3 receptor; P2Y6; P2Y6 receptor; Purinoceptor p2y6; pyrimidinergic receptor P2Y, G-protein coupled, 6; short splice variant; unnamed protein product
Gene Aliases: 2010204J23Rik; P2RY6; P2Y6; PP2891
UniProt ID: (Human) Q15077, (Rat) Q63371, (Mouse) Q9ERK9
Entrez Gene ID: (Human) 5031, (Rat) 117264, (Mouse) 233571
ADP receptor activity
G-protein coupled receptor activity
protein binding
G-protein coupled purinergic nucleotide receptor activity
UDP-activated nucleotide receptor activity
UTP-activated nucleotide receptor activity
signal transducer activity
pyrimidine nucleotide binding
G-protein coupled receptor
phagocytosis
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
transepithelial chloride transport
positive regulation of inositol trisphosphate biosynthetic process
G-protein coupled purinergic nucleotide receptor signaling pathway
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of ERK1 and ERK2 cascade
cellular response to prostaglandin E stimulus
cellular response to purine-containing compound
cellular response to oxygen-containing compound
positive regulation of vascular smooth muscle cell proliferation
cellular response to pyrimidine ribonucleotide
positive regulation of smooth muscle cell migration
cellular response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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