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Invitrogen
P3H3 Polyclonal Antibody
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Product Details
PA5-106424
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human P3H3(Accession Q8IVL6), corresponding to amino acid residues D578-E628.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total P3H3.
Target Information
The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gene rich cluster, B; leprecan-like 2; Leprecan-like protein 2; procollagen-proline 3-dioxygenase; Prolyl 3-hydroxylase 3; Protein B; unnamed protein product
Gene Aliases: BC016431; GRCB; HSU47926; LEPREL2; P3H3
UniProt ID: (Human) Q8IVL6, (Mouse) Q8CG70
Entrez Gene ID: (Human) 10536, (Rat) 297595, (Mouse) 14789
iron ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
procollagen-proline 3-dioxygenase activity
L-ascorbic acid binding
metal ion binding
dioxygenase activity
molecular_function
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
extracellular matrix glycoprotein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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