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Invitrogen
P4HA1 Polyclonal Antibody
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Product Details
PA5-87967
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 235-534 of human P4HA1 (NP_0010179621)
Conjugate
Form
Liquid
Concentration
1.02 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-87MG, LO2, A-431, 293T; Cellular Location: Endoplasmic reticulum lumen
Immunogen sequence: DPEHQRANGN LKYFEYIMAK EKDVNKSASD DQSDQKTTPK KKGVAVDYLP ERQKYEMLCR GEGIKMTPRR QKKLFCRYHD GNRNPKFILA PAKQEDEWDK PRIIRFHDII SDAEIEIVKD LAKPRLRRAT ISNPITGDLE TVHYRISKSA WLSGYENPVV SRINMRIQDL TGLDVSTAEE LQVANYGVGG QYEPHFDFAR KDEPDAFKEL GTGNRIATWL FYMSDVSAGG ATVFPEVGAS VWPKKGTAVF WYNLFASGEG DYSTRHAACP VLVGNKWVSN KWLHERGQEF RRPCTLSELE
Target Information
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4-PH alpha-1; C-P4Halpha(I); collagen prolyl 4-hydroxylase alpha(I); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase alpha subunit; Prolyl 4-hydroxylase subunit alpha-1; prolyl 4-hydroxylase, alpha polypeptide I
Gene Aliases: AL022634; P4HA; P4HA1; PHalphaI
UniProt ID: (Human) P13674, (Mouse) Q60715, (Rat) P54001
Entrez Gene ID: (Human) 5033, (Mouse) 18451, (Rat) 64475
procollagen-proline 4-dioxygenase activity
iron ion binding
protein binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
L-ascorbic acid binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
metal ion binding
dioxygenase activity
protein modifying enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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