PA5-27761 targets P4HA2 in WB applications and shows reactivity with Human samples.
The PA5-27761 immunogen is recombinant fragment corresponding to a region within amino acids 86 and 466 of Human P4HA2.
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This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
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Protein Aliases: 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); 2-oxoglutarate-4-dioxygenase subunit alpha-2; 4-PH alpha 2; 4-PH alpha-2; alpha polypeptide II; C-P4Halpha(II); collagen prolyl 4-hydroxylase alpha(II); procollagen-proline; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; prolyl 4-hydr; Prolyl 4-hydroxylase subunit alpha-2; prolyl 4-hydroxylase, alpha polypeptide II
Gene Aliases: P4HA2; UNQ290/PRO330
UniProt ID: (Human) O15460
Entrez Gene ID: (Human) 8974