Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-06105 detects Lamin C in human samples.
PA1-06105 has sucessfully been used in FACS, immunohistochemistry (frozen), and Western blotting procedures. By Western blot PA1-06105 detects a protein representing Lamin C.
The PA1-06105 immmunogen is a synthetic peptide corresponding to the C-terminal residues K H H V S G S R R of lamin C.
Store at 4°C, or in small aliquots at -20°C
Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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