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Invitrogen
Phospho-RSK1 (Ser221) Polyclonal Antibody
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Product Details
PA1-24769
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of human RSK1 containing serine 221.
Conjugate
Form
Liquid
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
PA1-24769 detects RSK1 p90 (phospho S221) from human samples. PA1-24769 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology. Cross reactivity with RSK2 is expected (100% conserved). Cross reactivity with RSK3 (80% homology) and RSK4 (90% homology) is possible but has not been tested. Not yet tested in other species.
PA1-24769 has been successfully used in Western blot procedures. A431 and NIH3T3 cells treated with PMA can be used as a positive control for this antibody.
The PA1-24769 immunogen is a synthetic phosphopeptide corresponding to a portion of human RSK1 containing serine 221.
Store at 4C short term. For extended storage, aliquot and store at -20C or below, avoiding freeze-thaw cycles.
Target Information
RPS6KA1 (RSK1) is a growth-factor regulated serine/threonine kinase that is involved in the MAPK cascade. It is thought to control cellular proliferation and differentiation through the phosphorylation of transcription factors. RPS6KA1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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