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Invitrogen
Phospho-c-Met (Tyr1349) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-c-Met (Tyr1349) Antibody (PA1-28464) in WB
Western blot detection of Phospho-c-Met pTyr1349 in extracts prepared from 293T cells expressing human c-Met and stimulated with HGF. Samples were resolved by SDS-PAGE on a 10% Tris-glycine gel and transferred to PVDF. Membranes were blocked with a 5% BSA-TBST buffer overnight at 4°C and probed using a Phospho-c-Met pTyr1349 polyclonal antibody (Product # PA1-28464).
Product Details
PA1-28464
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide derived from the region of c-Met that contains tyrosine 1349.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
25 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
Product Specific Information
PA1-28464 detects c-Met from human samples.
PA1-28464 has been successfully used in Western blot applications.
The PA1-28464 immunogen is: Synthetic phosphopeptide derived from the region of c-Met that contains tyrosine 1349.
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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