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Invitrogen

Lactoferrin Polyclonal Antibody

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Product Details

PA1-40307

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50
-

ELISA (ELISA)

1:50
-

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Bovine / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Human lactoferrin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1076386

Product Specific Information

PA1-40307 detects Lactoferrin from human samples.

PA1-40307 has been successfully used in ELISA, immunoprecipitation and Western blot applications.

The PA1-40307 imunogen is human lactoferrin.

Target Information

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; HLF; HLF2; iron binding protein; transferrin family member; iron transfer protein; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; neutrophil lactoferrin; Talalactoferrin; unnamed protein product

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Gene Aliases: GIG12; HEL110; HLF2; LF; LTF

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UniProt ID: (Human) P02788

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Entrez Gene ID: (Human) 4057

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Function(s)
lipopolysaccharide binding DNA binding serine-type endopeptidase activity cysteine-type endopeptidase inhibitor activity iron ion binding protein binding heparin binding peptidase activity serine-type peptidase activity hydrolase activity protein serine/threonine kinase activator activity metal ion binding membrane destabilizing activity
Process(es)
ossification regulation of cytokine production innate immune response in mucosa immune system process proteolysis ion transport iron ion transport humoral immune response antibacterial humoral response antifungal humoral response killing of cells of other organism negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway defense response to bacterium negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral process negative regulation of viral genome replication innate immune response positive regulation of osteoblast differentiation negative regulation of membrane potential negative regulation of viral process defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity cytolysis by host of symbiont cells bone morphogenesis antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of protein serine/threonine kinase activity positive regulation of bone mineralization involved in bone maturation negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development
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