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Invitrogen
TRPV1 Polyclonal Antibody
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FIGURE: 1 / 16
TRPV1 Antibody (PA1-748) in IHC (F)
Frozen human skin tissue sections were fixed with paraformaldehyde and stained with PA1-748 (1:250) followed by a biotin-conjugated donkey anti-rabbit IgG secondary antibody and streptavidin-HRP/tyrimide-fluorescent detection system. Vanilloid Receptor 1 staining is shown in red. Data courtesy of the Innovators Program.
Product Details
PA1-748
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues T(7) D L G A A A D P L Q K D T C(21) of human VR1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-748 detects vanilloid receptor 1 (VR1) from human bladder and skin.
PA1-748 has been successfully used in immunofluorescence and immunohistochemistry procedures. Immunohistochemical staining of VR1 in human glabrous skin using this antibody results in the staining of epidermal and dermal cells, as well as free nerve fibers and Merkel cells. Immunofluorescent staining of VR1 in human prostatic urethra using PA1-748 results in fibrous staining within the epithelial cells.
The PA1-748 immunogen is a synthetic peptide corresponding to residues T(7) D L G A A A D P L Q K D T C(21) of human VR1. PA1-748 immunizing peptide (Cat. # PEP-202) is available for use in neutralization and control experiments.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Capsaicin receptor; DKFZp434K0220; ion channel; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; truncated capsaicin receptor protein; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; VR1; VR1 receptor
Gene Aliases: TRPV1; VR1
UniProt ID: (Human) Q8NER1
Entrez Gene ID: (Human) 7442
nucleotide binding
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
voltage-gated calcium channel activity
calcium channel activity
protein binding
calmodulin binding
ATP binding
calcium-release channel activity
phosphatidylinositol binding
metal ion binding
phosphoprotein binding
temperature-gated ion channel activity
negative regulation of transcription from RNA polymerase II promoter
temperature homeostasis
fever generation
diet induced thermogenesis
peptide secretion
lipid metabolic process
ion transport
calcium ion transport
cell surface receptor signaling pathway
chemosensory behavior
response to pH
response to heat
urinary bladder smooth muscle contraction
sensory perception of pain
calcium-mediated signaling
ion transmembrane transport
cellular response to heat
response to pain
behavioral response to pain
sensory perception of taste
sensory perception of mechanical stimulus
thermoception
detection of temperature stimulus involved in thermoception
detection of temperature stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
protein homotetramerization
transmembrane transport
excitatory postsynaptic potential
smooth muscle contraction involved in micturition
calcium ion transmembrane transport
cellular response to alkaloid
cellular response to ATP
cellular response to acidic pH
calcium ion import across plasma membrane
response to capsazepine
calcium ion import into cytosol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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