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Invitrogen
RPGR Polyclonal Antibody
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Product Details
PA5-102497
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RPGR(Accession Q92834), corresponding to amino acid residues L974-L1020.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RPGR.
Target Information
This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mRpgr; retinitis pigmentosa 15; retinitis pigmentosa 3 GTPase regulator; unnamed protein product; X-linked retinitis pigmentosa GTPase regulator; XLRP3
Gene Aliases: COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3; Rp3h; RPGR; XLRP3
UniProt ID: (Human) Q92834, (Mouse) Q9R0X5
Entrez Gene ID: (Human) 6103, (Mouse) 19893, (Rat) 367733
ubiquitin-dependent protein catabolic process
intracellular protein transport
visual perception
positive regulation of autophagy
protein ubiquitination
cell projection organization
intraciliary transport
eye photoreceptor cell development
cilium organization
cilium morphogenesis
protein localization to nonmotile primary cilium
cilium assembly
response to stimulus
retina morphogenesis in camera-type eye
cellular response to light stimulus
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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