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Invitrogen

Phospho-RET (Tyr1096) Polyclonal Antibody

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Phospho-RET (Tyr1096) Polyclonal Antibody

Product Details

PA5-105796

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RET(Accession P07949), corresponding to amino acid residues around phosphorylated Tyr1096.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817195

Product Specific Information

Antibody detects endogenous levels of Ret only when phosphorylated at Tyr1096.

Target Information

The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cadherin family member 12; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); cadherin-related family member 16; EC 2.7.10.1; ELKS; Hydroxyaryl protein kinase; kinase Ret; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; receptor tyrosine kinase; ret; RET ELE1; Ret gene for receptor tyrosin; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); RET receptor tyrosine kinase; unnamed protein product

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Gene Aliases: c-Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51; RET9

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UniProt ID: (Human) P07949, (Mouse) P35546, (Rat) G3V9H8

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Entrez Gene ID: (Human) 5979, (Mouse) 19713, (Rat) 24716

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity calcium ion binding protein binding ATP binding kinase activity transferase activity signaling receptor activity transferase activity, transferring phosphorus-containing groups molecular_function transmembrane signal receptor
Process(es)
MAPK cascade ureteric bud development neural crest cell migration embryonic epithelial tube formation cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules neuron cell-cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance posterior midgut development positive regulation of gene expression positive regulation of neuron projection development regulation of cell adhesion neuron differentiation positive regulation of cell migration membrane protein proteolysis positive regulation of cell adhesion mediated by integrin ureter maturation glial cell-derived neurotrophic factor receptor signaling pathway neuron maturation positive regulation of MAPK cascade positive regulation of cell size positive regulation of transcription, DNA-templated response to pain enteric nervous system development regulation of axonogenesis positive regulation of protein kinase B signaling Peyer's patch morphogenesis cellular response to retinoic acid positive regulation of metanephric glomerulus development lymphocyte migration into lymphoid organs GDF15-GFRAL signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process anatomical structure morphogenesis positive regulation of neuron maturation phosphorylation peptidyl-tyrosine phosphorylation innervation response to drug retina development in camera-type eye
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