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Invitrogen
PNAS4 Polyclonal Antibody
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FIGURE: 1 / 2
PNAS4 Antibody (PA5-106335) in IHC (P)
Immunohistochemistry analysis of PNAS4 in mouse spleen tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PNAS4 polyclonal antibody (Product # PA5-106335) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106335
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DESI2(Accession Q9BSY9), corresponding to amino acid residues T21-E71.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PPPDE1/PNAS4.
Target Information
PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DeSI-2; desumoylating isopeptidase 1; Desumoylating isopeptidase 2; Deubiquitinase DESI2; family with sequence similarity 152, member A; Palmitoyl protein thioesterase DESI2; PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; Protein FAM152A; S-depalmitoylase DESI2
Gene Aliases: 5830417C01Rik; C1orf121; CGI-146; DESI; DeSI-2; DESI1; DESI2; FAM152A; PNAS-4; PPPDE1
UniProt ID: (Human) Q9BSY9, (Rat) Q5XIT6, (Mouse) Q9D291
Entrez Gene ID: (Human) 51029, (Rat) 289277, (Mouse) 78825
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
palmitoyl-(protein) hydrolase activity
hydrolase activity
long-chain acyl-CoA hydrolase activity
Lys63-specific deubiquitinase activity
ubiquitinyl hydrolase activity
Lys48-specific deubiquitinase activity
molecular_function
cysteine protease
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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