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Invitrogen
CTDSP1 Polyclonal Antibody
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FIGURE: 1 / 2
CTDSP1 Antibody (PA5-106634) in WB
Western blot analysis of CTDSP1 in extracts from various samples. Samples were incubated with CTDSP1 polyclonal antibody (Product # PA5-106634). Lane 1: Rat liver, blocked with antigen-specific peptides; Lane 2: Rat liver; Lane 3: Mouse kidney; Lane 4: HepG2 cells; Lane 5: 293 cells (LPS 4h treatment).
Product Details
PA5-106634
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CTDSP1(Accession Q9GZU7), corresponding to amino acid residues M1-L39.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CTDSP1.
Target Information
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; GIP; Golli-interacting protein; NLI-IF; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; SCP1 splice variant; Small C-terminal domain phosphatase 1; small CTD phosphatase 1
Gene Aliases: CTDSP1; GIP; NIF3; NLI-IF; NLIIF; SCP1
UniProt ID: (Human) Q9GZU7, (Mouse) P58466
Entrez Gene ID: (Human) 58190, (Rat) 363249, (Mouse) 227292
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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