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Invitrogen
GFR alpha-1 (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
GFR alpha-1 (extracellular) Antibody (PA5-111868) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of GFR alpha-1 in live intact live intact rat C6 glioma cells using GFR alpha-1 (extracellular) Antibody (Product # PA5-111868) (1:50), followed by goat-anti-rabbit-DyLight-594 secondary antibody (red) (A). B) Live view of the cells. C) Merge of the two images.
Product Details
PA5-111868
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 72-83 of rat GFRA1 (Extracellular domain)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
40 µg
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: CRSAMEALKQ KS
Homology: Mouse, human amino acid residues are identical.
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR-a-1 recently. GFR-a-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR-a and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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