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Invitrogen
PAK3 Polyclonal Antibody
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Product Details
PA5-112638
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Serine/threonine-protein kinase PAK 3 protein (70-190AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.11.1; adriamycin resistance-associated; Beta-PAK; CDC42/RAC effector kinase PAK-B; CDKN1A; hPAK3; Oligophrenin-3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; PAK beta; PAK-3; Serine/threonine-protein kinase PAK 3; unnamed protein product
Gene Aliases: ARA; beta-PAK; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3; PAK3beta; Pak65alpha; Pak65beta; Pakb; Stk4; XLID30
UniProt ID: (Human) O75914, (Mouse) Q61036
Entrez Gene ID: (Human) 5063, (Mouse) 18481
nucleotide binding
catalytic activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
SH3 domain binding
small GTPase binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
Rho GTPase binding
Rac GTPase binding
GTPase binding
MAPK cascade
stimulatory C-type lectin receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
axonogenesis
cellular response to starvation
dendrite development
cell migration
regulation of actin filament polymerization
regulation of actin cytoskeleton organization
intracellular signal transduction
regulation of MAPK cascade
ephrin receptor signaling pathway
regulation of axonogenesis
synapse organization
dendritic spine development
dendritic spine morphogenesis
regulation of postsynapse organization
regulation of actin filament organization
activation of MAPK activity
protein phosphorylation
Rho protein signal transduction
multicellular organism development
regulation of mitotic cell cycle
metabolic process
regulation of neuron projection development
phosphorylation
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of dendritic spine morphogenesis
cellular response to organic cyclic compound
positive regulation of DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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