Search
Invitrogen
KCNK2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 6
KCNK2 Antibody (PA5-114332) in IHC (P)
Immunohistochemical analysis of KCNK2 in paraffin-embedded rat adrenaline tissue using a polyclonal antibody (Product #PA5-114332). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:100) for 30 minute... View More
Product Details
PA5-114332
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within Human KCNK2 aa 7-56.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: arachidonic acid sensitive tandem pore domain potassium channel; hTREK-1c; hTREK-1e; ion transport membrane protein; K2P2.1; K2P2.1 potassium channel; kcnk2 {ECO:0000312|EMBL:AAU06141.1, ECO:0000312|Ensembl:ENSRNOP00000003684, ECO:0000312|RGD:621448}; Outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250|UniProtKB:O95069}; Potassium channel subfamily K member 2; potassium channel subfamily K member 2 {ECO:0000250|UniProtKB:O95069}; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303|PubMed:16248991}; tandem-pore-domain potassium channel TREK-1; trek 1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250|UniProtKB:O95069}; TWIK-related potassium channel 1; two pore domain K+ channel subunit; Two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303|PubMed:24196565}; Two pore domain potassium channel TREK1; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250|UniProtKB:O95069}; two-pore potassium channel 1; two-pore-domain potassium channel subunit; unnamed protein product
Gene Aliases: A430027H14Rik; AI848635; hTREK-1c; hTREK-1e; K2p2.1; KCNK2; rTREK1d; TPKC1; TREK; TREK-1; TREK1
UniProt ID: (Human) O95069, (Rat) Q920B6, (Mouse) P97438
Entrez Gene ID: (Human) 3776, (Rat) 170899, (Mouse) 16526
voltage-gated potassium channel activity
potassium channel activity
outward rectifier potassium channel activity
potassium channel inhibitor activity
ligand-gated channel activity
potassium ion leak channel activity
identical protein binding
metal ion binding
protein heterodimerization activity
mechanically-gated potassium channel activity
protein binding
voltage-gated ion channel activity
ion channel
transporter
cardiac ventricle development
ion transport
potassium ion transport
G-protein coupled receptor signaling pathway
memory
response to mechanical stimulus
glutamate secretion
neuronal action potential
regulation of synaptic transmission, GABAergic
ion transmembrane transport
regulation of membrane potential
response to axon injury
detection of mechanical stimulus involved in sensory perception of touch
negative regulation of cardiac muscle cell proliferation
cellular response to hypoxia
potassium ion transmembrane transport
cochlea development
chemical synaptic transmission, postsynaptic
positive regulation of cellular response to hypoxia
chloride transmembrane transport
cellular response to arachidonate
negative regulation of DNA biosynthetic process
transport
positive regulation of cell death
stabilization of membrane potential
regulation of ion transmembrane transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support