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FIGURE: 1 / 3
Positive Samples: U-87MG, K-562
Immunogen sequence: HQDLQFAGLL NPLDSPHHMR QDEESEFREG IVVDRPTRPG HGSFVNCGMK KEVKIDKNLE PGLRVTVRLN QQQHPDCKTY HGKVVSSQDP RTKAGLYWGY TVRLASCLSA VFAEAPFQDG YDLTIGTSER GSDVASAQLP NFRHALVVFG GLQGLEAGAD ADPNLEVAEP SVLFDLYV
C9orf114 is a protein coding gene. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level.
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Protein Aliases: CENP-32; Centromere protein 32; Kinetochore-associated protein; Putative methyltransferase C9orf114; SPOUT domain-containing methyltransferase 1; uncharacterized protein C9orf114 homolog
Gene Aliases: C9orf114; CENP-32; HSPC109; SPOUT1
UniProt ID: (Human) Q5T280
Entrez Gene ID: (Rat) 499770, (Human) 51490
Molecular Function: methyltransferase
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