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Invitrogen
Phospho-delta Catenin (Tyr257) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-delta Catenin (Tyr257) Antibody (PA5-118686) in IHC (P)
Immunohistochemical analysis of Phospho-delta Catenin (Tyr257) in Mouse kidney tissue using a Phospho-delta Catenin (Tyr257) polyclonal antibody (Product # PA5-118686). The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was ... View More
Product Details
PA5-118686
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CTNND1(Accession O60716), corresponding to amino acid residues around phosphorylated Tyr257.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of CTNND1 only when phosphorylated at Tyr257.
Target Information
Delta 1 Catenin is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin-associated Src substrate; Cadherin-associated Src substrate (CAS); CAS; Catenin (cadherin associated protein) delta 1; catenin (cadherin-associated protein), delta 1; Catenin delta-1; catenin src; hp120ctn-1A; hp120ctn-1AB; hp120ctn-1ABC; hp120ctn-1AC; hp120ctn-1B; hp120ctn-2A; hp120ctn-2AB; hp120ctn-2ABC; hp120ctn-2AC; hp120ctn-2B; hp120ctn-3A; hp120ctn-3AB; hp120ctn-3ABC; hp120ctn-3AC; hp120ctn-3B; hp120ctn-4A; hp120ctn-4AB; hp120ctn-4ABC; hp120ctn-4AC; hp120ctn-4B; p120 catenin; P120 CTN; P120 p120; P120 P120CTN; p120(cas); p120(ctn); p120-catenin; unnamed protein product
Gene Aliases: AA409437; AU019353; BCDS2; CAS; Catns; CTNND; CTNND1; KIAA0384; mKIAA0384; P120; p120(CAS); p120(CTN); P120CAS; P120CTN
UniProt ID: (Human) O60716, (Mouse) P30999
Entrez Gene ID: (Human) 1500, (Mouse) 12388, (Rat) 311163
receptor binding
protein binding
phosphatase inhibitor activity
phosphatase binding
cadherin binding
protein binding involved in cell-cell adhesion
protein sequestering activity
protein kinase binding
protein phosphatase binding
protein domain specific binding
cell adhesion molecule binding
intermediate filament binding protein
negative regulation of transcription from RNA polymerase II promoter
cell migration involved in sprouting angiogenesis
cell adhesion
negative regulation of glucose transport
Wnt signaling pathway
cell-cell adhesion mediated by cadherin
protein stabilization
cell-cell adhesion
regulation of postsynaptic membrane neurotransmitter receptor levels
positive regulation of protein localization to cell-cell junction
negative regulation of intracellular signal transduction
glucose transmembrane transport
negative regulation of blood vessel branching
morphogenesis of a polarized epithelium
transcription, DNA-templated
regulation of transcription, DNA-templated
salivary gland morphogenesis
single organismal cell-cell adhesion
keratinocyte differentiation
epithelial cell differentiation involved in salivary gland development
negative regulation of canonical Wnt signaling pathway
brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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