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Invitrogen
Phospho-ALK (Tyr1078) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-ALK (Tyr1078) Antibody (PA5-118766) in IHC (P)
Immunohistochemical analysis of Phospho-ALK (Tyr1078) in Mouse brain tissue using a Phospho-ALK (Tyr1078) polyclonal antibody (Product # PA5-118766). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary... View More
Product Details
PA5-118766
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ALK(Accession Q9UM73), corresponding to amino acid residues around phosphorylated Tyr1078.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of ALK only when phosphorylated at Tyr1078.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; npm-alk; p80; TFG/ALK; unnamed protein product
Gene Aliases: ALK; ALK1; CD246; NBLST3; Tcrz
UniProt ID: (Human) Q9UM73, (Mouse) P97793
Entrez Gene ID: (Human) 238, (Mouse) 11682
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
heparin binding
kinase activity
transferase activity
receptor signaling protein tyrosine kinase activator activity
identical protein binding
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
response to stress
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
brain development
phosphorylation
hippocampus development
adult behavior
swimming behavior
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
regulation of apoptotic process
regulation of neuron differentiation
protein autophosphorylation
neuron development
negative regulation of lipid catabolic process
positive regulation of NF-kappaB transcription factor activity
regulation of dopamine receptor signaling pathway
regulation of primary metabolic process
response to environmental enrichment
energy homeostasis
positive regulation of dendrite development
activation of MAPK activity
protein phosphorylation
peptidyl-tyrosine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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